Regulation of prostaglandin E2 receptors in vivo by dietary fatty acids in peritoneal macrophages from rats.
نویسندگان
چکیده
منابع مشابه
Regulation of prostaglandin E2 receptors in vivo by dietary fatty acids in peritoneal macrophages from rats.
Groups of rats were pretreated with 4-week diets containing 12.5% corn oil or linseed oil. At the end of this period peritoneal macrophages were elicited and isolated. These cells were used for binding experiments with 3H-PGE2 and for estimation of prostaglandin-stimulated cAMP production. Specific binding of 3H-PGE2 was saturable, reversible, protein-dependent, and correlated with stimulation ...
متن کاملEffects of dietary polyunsaturated fatty acids on ovarian function and prostaglandin secretion in lactating dairy cows
As lactating cows in severe negative energy balance have poor reproductive performance, the effect of dietary fat supplementation (fish oil, soybean oil) on PGFM secretion, ovarian function and blood metabolites is investigated. In this experiment, the effects of dietary polyunsaturated fatty acids on plasma metabolites, ovarian function and prostaglandin secretion of 20 primiparous Holstein co...
متن کاملRegulation of purinergic signaling by prostaglandin E2 in murine macrophages.
Extracellular nucleotides are primary signals for tissue injury, acting together with various chemical mediators such as prostanoids at the inflammatory site. We investigated whether prostaglandin E2 (PGE2) affects purinergic signaling in murine J774 macrophages. J774 cells expressed four different purinoceptor mRNAs: the ionotropic P2X4 and P2X7 receptors and G-protein-coupled P2Y2 and P2Y6 re...
متن کاملScreening and identification of dietary oils and unsaturated fatty acids in inhibiting inflammatory prostaglandin E2 signaling in fat stromal cells
BACKGROUND The molecular mechanisms of dietary oils (such as fish oil) and unsaturated fatty acids, which are widely used by the public for anti-inflammation and vascular protection, have not been settled yet. In this study, prostaglandin E(2) (PGE(2))-mediated calcium signaling was used to screen dietary oils and eight unsaturated fatty acids for identification of their anti-inflammatory mecha...
متن کاملInduction of Apoptosis in Thymocytes by Prostaglandin E2 In Vivo
In vivo administration in mice of a synthetic analog of prostaglandin E2 (PGE2) caused a selective and dramatic decrease of CD4+CD8+ double-positive, CD3/T-cell-receptor-alpha beta(lo) cells in the thymus. This loss was corticosteroid-independent and not affected by Cyclosporin A. The disappearance of CD4+CD8+ thymocytes was strictly correlated with the induction of apoptosis inside the thymus ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 1984
ISSN: 0022-2275
DOI: 10.1016/s0022-2275(20)37822-6